Our clinical research team conducts rigorous, peer-reviewed research into mast cell activation syndrome and related neuroinflammatory conditions. We partner with academic medical centers and clinical networks to understand disease mechanisms, evaluate new treatments, and improve patient outcomes through evidence-based research.
We're advancing the scientific understanding of mast cell activation and neuroinflammatory diseases through rigorous clinical research. Our mission is to generate high-quality evidence that transforms patient care, supports regulatory approvals for new treatments, and establishes new standards of care based on real-world data.
Investigating the underlying mechanisms of mast cell activation, including genetic factors, immune dysregulation, and trigger identification. Our studies combine biomarker analysis with patient symptom tracking to understand individual disease variations.
Conducting clinical trials evaluating both established and novel treatments for MCAS. We employ rigorous study designs with appropriate controls and meaningful outcome measures aligned with patient needs.
Collecting long-term outcomes data from patients in real clinical settings. This real-world evidence complements traditional trials and reveals how treatments perform outside controlled research environments.
Using biomarkers and clinical characteristics to identify patient subgroups with distinct treatment responses, enabling precision medicine approaches that match patients to optimal therapies.
Multi-center registry following hundreds of MCAS patients over 2+ years, collecting comprehensive clinical and biomarker data to understand natural history and treatment outcomes.
Identifying and validating novel biomarkers that predict disease progression, treatment response, and patient stratification using omics approaches.
Evaluating the relative benefits and harms of different treatment strategies using pragmatic trial designs that reflect real-world clinical practice.
Developing and validating outcome measures that capture what matters most to patients: symptom relief, quality of life, functional capacity, and wellbeing.
We collaborate with leading academic medical centers, specialty clinics, and patient organizations. Our research network includes sites across North America, enabling large-scale studies that are representative of diverse patient populations and clinical settings.
Our clinical research has contributed to improved diagnostic criteria, validated new biomarker panels for patient monitoring, and generated evidence supporting new treatment approaches. We've published 50+ peer-reviewed papers advancing the understanding of mast cell activation and related conditions.
We're seeking physicians, nurses, clinical researchers, statisticians, and research coordinators passionate about advancing clinical science. Help us conduct the research that changes clinical practice and improves patient lives.